Born Jamesetta Hawkins on January 25, 1938 in Los Angeles. As a child, Etta was a gospel prodigy, singing in her church choir and on the radio at the age of five. When she turned twelve, she moved north to San Francisco where she formed a trio and was soon working for bandleader Johnny Otis.In 1954, she moved to Los Angeles to record "The Wallflower" (a tamer title for the then-risqué "Roll with Me Henry") with the Otis band. It was that year that the young singer became Etta James (an inverted version of her first name) and her vocal group was dubbed The Peaches (also Etta's nickname). Soon after, James launched her solo career with such hits as "Good Rockin' Daddy" in 1955.

After signing with Chicago's Chess Records in 1960, James' career began to soar. Chart toppers included duets with then-boyfriend Harvey Fuqua, the heart-breaking ballad "All I Could Do Was Cry," "At Last" and "Trust in Me." But James' talents weren't reserved for powerful ballads. She knew how to rock a house, and did so with such gospel-charged tunes as "Something's Got a Hold On Me" in 1962 and "In The Basement" in 1966. James continued to work with Chess throughout the 1960s and early 1970s. Sadly, heroin addiction affected both her personal and professional life, but in 1967 Chess took her to the Fame studios to record with the Muscle Shoals house band. The collaboration resulted in the triumphant Tell Mama album.

Despite her continued drug problems, she earned a Grammy nomination for her 1973 album Etta James. After completing her contract with Chess in 1977, James signed on with Warner Brothers Records. A renewed public profile followed her appearance at the opening ceremony of the Los Angeles Olympics in 1984. Subsequent albums, including Deep In The Night and Seven Year Itch received critical acclaim. She was inducted into the Rock And Roll Hall Of Fame in 1993, prior to her signing a new recording contract with Private Records.

With suggestive stage antics and a sassy attitude, James continued to perform and record well into the 1990s. Always soulful, her extraordinary voice has been showcased to great effect on her recent Private releases, including Blue Gardenia, which rose to the top of the Billboard jazz chart. In 2003, James underwent gastric bypass surgery and lost over 200 pounds. The dramatic weight loss had an impact on her voice, as she told Ebony magazine that year. "I can sing lower, higher and louder," James explained.
That same year, Etta James released Let's Roll, which won the Grammy Award for Best Contemporary Blues Album. Her sons, Donto and Sametto James served as producers on the recording along with Josh Sklair. This team regrouped for her next effort, Blues to the Bone (2004), which brought James her third Grammy Awardthis time in the Best Traditional Blues Album category.

In 2006, James released the album All the Way, which featured cover versions of songs by Prince, Marvin Gaye, and James Brown. She participated in a tribute album the following year for jazz great Ella Fitzgerald called We Love Ella.

The story of the early days of Chess Records was brought to the big screen as Cadillac Records in 2008, with singer Beyoncè Knowles playing Etta James in the film. Beyoncè also recorded her own version of James's signature song, "At Last" for the soundtrack.

While James publicly supported the film, she was reportedly miffed when Beyoncè sang the song at President Barack Obama's inaugural ball in January 2009. James allegedly told concert-goers in Seattle in February that Beyoncè "had no business...singing my song that I been singing forever. " Despite some media attention over her comments, James was unfazed by the incident and pressed on with her busy performing schedule.