How did the Indians respond to English settlement?

Sep 2012
So the teacher gave us these questions but I cannot find any sources (Especially pertaining to Jamestown)

What factors prevented them from resisting effectively?
All I could find was this - There were different factors that prevented the Indians from resisting effectively. To begin with, the technological advancements of the English including guns were far more lethal than the weapons used by the Indians.

Possibly smallpox which reduced their numbers?

What attempts were made by the Indians to overcome this?
Use deception against the colonists? One time presenting foods/gifts and then ambushing them. Don't know any thing else.

To what extent was their culture negatively affected?
Native Americans were pushed to the brink of disappearance, fighting off small pox and basically surviving off the land. Many of them also assimilated to Catholic culture.