The confrontation is decontextualized, and this is already a problem, but overall Alexander hadn't to fight a civil war against other great leaders of his own Republic. Alexander did expand the Greek Empire really more than Caesar did with the Roman domains, but Caesar had to face other great Roman leaders ... Alexander didn't face and defeat other great Macedonian leaders.
But I repeat, being the confrontation decontextualized, it's about instinctive preference more than about a rational and comprehensive evaluation.